Persistent gastroesophageal reflux is the predominant indication that will alert a physician to the potential of malignant degeneration. The symptoms may progress, suggesting a more serious pathology.

1. Gastroesophageal reflux

2. Dysphagia

3. Weight loss



Diagnosis is established at endoscopy with histologic confirmation of columnar epithelial cells extending at least 3 cm into the esophagus above the anatomic GE junction. Current definitions now include any length of metaplasia to be of significance.

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