Treatment of Stage I and Stage II is primarily surgery.

1. Wedge Resection

2. Segmentectomy

3. Lobectomy

4. Pneumonectomy

5. Sleeve Resection

Treatment for Stage IIIA remains controversial; however induction therapy has had up to 30% of patients resectable. The remaining stages are managed primarily with radiation and chemotherapy.

Stage I carcinoma of the lung can expect 3- and 5-year survival rates of approximately 85% and 70%, respectively. The most favorable group of patients with Stage I disease, those with T 1N 0 disease, experience 5-year survival rates of 80% to 85%. Neither chemotherapy nor radiation therapy is recommended after complete resection of Stage I lung cancer.

Surgical therapy includes resection of the primary tumor with resection of the hilar, interlobar, lobar, and segmental lymph nodes. In addition, systematic medias-tinal lymph node dissection is performed to exclude the presence of mediastinal metastases. Five-year survival rates of 40% to 50% are observed with a recurrence rate of greater than 50%. Postoperative radiation therapy may reduce the incidence of local and regional recurrence but does not affect overall survival.

This is a controversial area with current recommendations of resection combined with some form of adjuvant therapy.

Stage I

Stage II

Stage IIIa

Table 19.3.

Genetic factors in lung cacner




90% of lung cancers Decreased survival Increased survival when present




Tumor suppressor p53

Signal transduction Chemoresistance

Proto-oncogene inhibits apoptosis

DNA binding and cell cycle regulation

Cell cycle control and proliferation Cell cycle control and proliferation

90% of lung cancers Decreased survival Increased survival when present

Decreased survival

Cigarette Crusher

Cigarette Crusher

Get All The Support And Guidance You Need To Permanently STOP Being A Slave To Nicotine And Cigarettes. This Book Is One Of The Most Valuable Resources In The World When It Comes To Easy Ways To Eliminate Smoking Addiction And Revitalize Your Body.

Get My Free Ebook

Post a comment