Viral Transmission

As noted, fibrinogen is an essential factor in the glue and can be obtained from screened donor plasma minimizing the risk of hepatitis and HIV. Both fibrinogen and thrombin are subjected to a variety of treatments to minimize risk of HIV, hepatitis B and C, HTLV, EBV and CMV. Parvovirus B19 have been shown to be transmitted; however most patients have antibodies to this making any infection subclinical. Viral inactivation has been shown to be greater that 9 log10 to 19 log10 for HIV-1, HSV-1 in fibrinogen, factor XIII and thrombin.1 While the risk is low, it has not been eliminated (Table 3.7).

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