Betaadrenergic receptor agonists

1. Maternal side effects include tachycardia, palpitations, and lowered blood pressure. Myocardial ischemia is rare. Common side effects include chest discomfort (10 percent), shortness of breath (15 percent), palpitations (18 percent), tremor (39 percent) and anxiety. Pulmonary edema is an uncommon maternal complication, occurring in 0.3 percent.

2. Beta-adrenergic-receptor agonists may cause hypokalemia (39 percent), hyperglycemia (30 percent), and lipolysis. Glucose and potassium should be monitored. Neonatal hypoglycemia may result from fetal hyperinsulinemia due to prolonged maternal hyperglycemia.

3. Contraindications to beta-agonists. Beta-adrenergic-receptor agonists are relatively contraindicated among women with cardiac disease. Women with poorly controlled hyperthyroidism or diabetes mellitus should not receive these agents. Well-controlled diabetes mellitus is not a contraindication.

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