Maternal obstetrical factors associated with neonatal GBS disease

1. Delivery at less than 37 weeks of gestation

2. Premature rupture of membranes

3. Rupture of membranes for 18 or more hours before delivery

4. Chorioamnionitis

5. Temperature greater than 38°C during labor

6. Sustained intrapartum fetal tachycardia

7. Prior delivery of an infant with GBS disease

D. Manifestations of early-onset GBS disease. Early-onset disease results in bacteremia, generalized sepsis, pneumonia, or meningitis. The clinical signs usually are apparent in the first hours of life.

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