Contraindications to Methotrexate Therapy

Absolute contraindications

Breast feeding

Overt or laboratory evidence of immunodeficiency Alcoholism, alcoholic liver disease, or other chronic liver disease

Preexisting blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia, or significant anemia

Known sensitivity to methotrexate Active pulmonary disease Peptic ulcer disease

Hepatic, renal, or hematologic dysfunction Relative contraindications

Gestational sac >3.5 cm Embryonic cardiac motion

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