Treatment of acute uncomplicated cystitis in young women

1. Three-day regimens appear to offer the optimal combination of convenience, low cost and an efficacy comparable to that of seven-day or longer regimens.

2. Trimethoprim-sulfamethoxazole is the most cost-effective treatment. Three-day regimens of ciprofloxacin (Cipro), 250 mg twice daily, and ofloxacin (Floxin), 200 mg twice daily, produce better cure rates with less toxicity.

3. Quinolones that are useful in treating complicated and uncomplicated cystitis include ciprofloxacin, norfloxacin, ofloxacin, enoxacin (Penetrex), lomefloxacin (Maxaquin), sparfloxacin (Zagam) and levofloxacin (Levaquin).

4. Trimethoprim-sulfamethoxazole remains the antibiotic of choice in the treatment of uncomplicated UTIs in young women. Fluoroquinolones are recommended for patients who cannot tolerate sulfonamides or trimethoprim or who have a high frequency of antibiotic resistance. Three days is the optimal duration of treatment for uncomplicated cystitis. A seven-day course should be considered in pregnant women, diabetic women and women who have had symptoms for more than one week.

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