Evaluation

1. All women with atypical endocervical or glandular cells or AIS should be referred for colposcopy and sampling of the endocervical canal. Women over age 35 and younger women with AGC and unexplained or anovulatory bleeding also need an endometrial biopsy.

2. Women with only atypical endometrial cells on cytology can be initially evaluated with endometrial biopsy only, rather than colposcopy.

3. Positive findings, such as any grade of CIN on biopsy, should be managed as appropriate.

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