Indomethacin

1. Indomethacin is a nonspecific cyclooxygenase inhibitor. Indomethacin is significantly more effective than placebo.

2. Maternal side effects include nausea, esophageal reflux, gastritis, and emesis.

3. Fetal side effects. The primary fetal concerns with use of indomethacin are constriction of the ductus arteriosus and oligohydramnios.

4. Contraindications. Maternal contraindications include platelet dysfunction or bleeding disorder, hepatic dysfunction, gastrointestinal ulcerative disease, renal dysfunction, and asthma (in women with hypersensitivity to aspirin).

E. Recommendations. Beta-adrenergic agonists are the first-line agents for treatment of preterm labor. Indomethacin is recommended for women in PTL with gestations less than 32 weeks in which beta-agonists cannot be administered.

Herbal Remedies For Acid Reflux

Herbal Remedies For Acid Reflux

Gastroesophageal reflux disease is the medical term for what we know as acid reflux. Acid reflux occurs when the stomach releases its liquid back into the esophagus, causing inflammation and damage to the esophageal lining. The regurgitated acid most often consists of a few compoundsbr acid, bile, and pepsin.

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