Selective estrogen receptor modulators

1. Raloxifene (Evista) (5 mg daily or a once-a-week preparation) is a selective estrogen receptor modulator (SERM) for prevention and treatment of osteoporosis. It increases bone mineral density and reduces serum total and low-density-lipoprotein (LDL) cholesterol. It also appears to reduce the incidence of vertebral fractures and is one of the first-line drugs for prevention of osteoporosis.

2. Raloxifene is somewhat less effective than the bisphosphonates for the prevention and treat-

ment of osteoporosis. Venous thromboembolism is a risk.

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