Antepartum prophylaxis

1. Isoimmunized occurs in 1-2% of D-negative women during the antepartum period. D immu-noglobulin, administered both during pregnancy and postpartum, can reduce the incidence of D isoimmunization to 0.3%.

2. Antepartum prophylaxis is given at 28-29 weeks of gestation. Antibody-negative, Rh-negative gravidas should have a repeat assessment at 28 weeks. D immunoglobulin (RhoGAM, RhIg), 300 mcg, is given to D-negative women. However, if the father of the fetus is known with certainty to be D negative, antepartum prophylaxis is not necessary.

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