Prenatal testing

A. Routine prenatal laboratory evaluation includes ABO and D blood type determination and antibody screen.

B. At 28-29 weeks of gestation woman who are D negative but not D isoimmunized should be re-tested for D antibody. If the test reveals that no D antibody is present, prophylactic D immunoglobulin [RhoGAM, Rho(D) immunoglobulin, RhIg] is indicated.

C. If D antibody is present, D immunoglobulin will not be beneficial, and specialized management of the D isoimmunized pregnancy is undertaken to manage hemolytic disease of the fetus and hydrops fetalis.

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