A. The definitive diagnosis is made by pathological evaluation of tissue.

B. A combination of clinical breast examination, mammography, and fine-needle aspiration and biopsy may be sufficient to make a diagnosis. If all studies are "benign," there is a greater than 99% chance that a benign breast lesion is present.

C. Open biopsy in the operating room or wire-localization of a suspicious lesion noted on mammography may be necessary if fine-needle aspiration and biopsy is nondiagnostic. Biopsy by stereo-tactic technique in radiology also may be used to obtain tissue for diagnosis of the suspicious area.

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