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INTRODUCTION Also known as a calcifying epithelioma of Malherbe, pilomatrixoma is a benign tumor of the hair cortical cells. The lesion tends to occur in children and young adults, with 75% less than 10 years of age. The head and upper extremities are the most common sites of involvement with a significant proportion occurring in the periorbital region, particularly the upper eyelid and brow. Most lesions are misdiagnosed as epidermoid and dermoid cysts, and are unsuspected until histopathologic examination.

CLINICAL PRESENTATION Usually solitary, these slowing growing lesions appear as a solid or cystic, mobile, subcutaneous nodule with normal overlying skin. They are firm, irregular, masses with the overlying skin showing a pink or blue discoloration. In 15% to 18% of cases the lesion can be associated with pain or inflammation. Stretching the overlying skin taut may reveal a whitish, multifaceted tumor, the so-called "tent sign." Dilated vessels may be seen on the tumor surface.

Dermoid Cyst Pictures Eye Brow
(Courtesy of Peter Rubin, M.D.)

HISTOPATHOLOGY Pilomatrixomas are composed of islands of basophilic cells surrounding eosinophilic shadow cells. The basophilic cells have little cytoplasm, indistinct cell borders, hyperchromatic nuclei, and abundant mitoses. Eosinophilic shadow cells represent mummified basophilic cells and have more cytoplasm and distinct, though faint, cell borders. There may be abrupt transition from the basophilic cells to the eosinophilic shadow cells, or there may be an intermediate zone of transitional cells that develop progressively more eosinophilic cytoplasm while the nucleus becomes pyknotic. Foci of calcification are very common. Pilomatrixomas are dermal lesions that often extend into the subcutis.

Pilomatrixoma Children

DIFFERENTIAL DIAGNOSIS Differential diagnosis includes epidermoid and dermoid cysts, sebaceous cyst, squamous cell carcinoma, and vascular lesions.

These lesions do not regress. Treatment is with surgical excision including the overlying skin. Incomplete removal is associated with recurrence.

Agarwal RP, Handler SD, Matthews MR, Carpentieri D. Pilomatrixoma of the head and neck in children. Otolaryngol

Head and Neck Surg 2001; 125:510-515. Cahill MT, Moriarty PM, Mooney DJ, Kennedy SM. Pilomatrixoma carcinoma of the eyelid. Am J Ophthalmol 1999; 127:463-464.



Duflo S, Nicollas R, Roman S, Magalon G, Triglia JM. Pilomatrixoma of the head and neck in children: a study of 38 cases and a review of the literature. Arch Otolaryngol Head Neck Surg 1998; 124:1239-1242.

Huerva V, Sanchez MC, Asenjo J. Large, rapidly growing pilomatrixoma of the upper eyelid. Ophthal Plast Reconstr Surg 2006; 22:401-403.

Jang HS, Park JH, Kim MB, Kwon KS, Oh CK. Two case of multiple giant pilomatrixoma. J Dermatology 2000; 24:276-279.

Mathen LC, Olver JM, Cree IA. A large rapidly growing pilomatrixoma on a lower eyelid. Br J Ophthalmol 2000; 84:1203-1204.

Moehlembeck FW. Pilomatrixoma. Arch Dermatol 1973; 108:532-534.

O'Grady R, Spoerl G. Pilomatrixoma (benign calcifying epithelioma of Malherbe). Ophthalmology 1981; 88:1196-1197.

Orlando RG, Rogers GL, Bremer DL. Pilomatrixoma in a pediatric hospital. Arch Ophthalmol 1983; 101:1209-1210.

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Shields JA, Shields CL, Eagle RC JR, Mulvey L. Pilomatrixoma of the eyelid. J Pediatr Ophthalmol Strabismus 1995; 32: 260-261.

Yap EY, Hoberger GG, Bartley GB. Pilomatrixoma of the eyelids and eyebrows in children and adolescents. Ophthal Plast Reconstruct Surg 1999; 15:185-189.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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