Glandular and Cystic Hyperplasia of the Endocervix [33400

The physiologic hyperstimulation of the endocervical mucosa during gestation induces a mild or moderate hypersecretion of the glands and a proliferation of reserve cells (Fig. 56). The ectropionized mucosa usually is overgrown by an ascending regenerative epithelium (Fig. 55). Foci of ectopic decidua may be found in the endocervix and appear much like those seen at various other sites throughout the small pelvis during pregnancy. They show that they possess the inherent genetic potentialities of Mullerian-derived cells. In like manner, an Arias-Stella reaction [7943/0] (see Figs. 57,58) is also occasionally observed in endocervical glands.

Effects of Endogenous Progesterone under Hypersecretion

Effects of Endogenous Progesterone under Hypersecretion

Arias Stella Reaction
Fig. 55. Glandular (and cystic) hyperplasia of endocervix during pregnancy, with proliferation of reserve cells. H&E
Glandular Cervix
Fig. 56. Glandular (and cystic) hyperplasia of endocervix during pregnancy, with proliferation of reserve cells. H&E, higher magnification
Arias Stella Effect
Fig. 58. Arias-Stella reaction of endocervical glandular epithelia during pregnancy. Hyperplastic endocervical epithelia with hobnail nuclei. H&E, higher magnification of Fig. 57
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