Mesonephric Duct Remnants [26370 and Hyperplasia [72580

Remnants of the mesonephric duct (Gartner's duct) are occasionally found deep in the lateral cervical wall (Fig. 32). They consist of small round tubules lined by a single layer of low cuboidal epithelium which contains no glycogen or mucin, whereas in the lumina one often finds eosinophilic homogenous material (Fig. 34) which is PAS-positive (compare Fig. 207). The tubules are often arranged in clusters, occasionally around an elongated remnant of a larger tubule (Fig. 33). Mesonephric duct hyperplasia consists of larger aggregates of such tubules, which may even penetrate the entire cervical wall (florid type) (Fig. 209).

■ Differential Diagnosis. Hyperplasia must be carefully distinguished from: (a) meso-nephric adenocarcinoma, which shows hobnail cells with cytological atypia, intraglan-dular epithelial papillae, and frank stromal invasion; and (b) minimal deviation adenocarcinoma of the endocervix, which shows intracellular mucin formation, a positive re-

Mesonephric Hyperplasia Cervix
Fig. 32. Remnants of mesonephric duct in the cervical wall. H&E

Mesonephric Duct Remnants [2637/0] and Hyperplasia [7258/0]

action with CEA, periglandular edema with mucin pools, a desmoplastic stromal reaction around the invading tubules, and a histological transition between normal endo-cervical glands and the carcinomatous tubules (Shah et al. 1980; Ayroud et al. 1985).

Mesonephric Ducts Endocervix
Fig. 33. Remnants of mesonephric duct in the cervical wall. H&E
Mesonephric Duct Cervix
Fig. 34. Remnants of mesonephric duct in the cervical wall. H&E, higher magnification
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