Classic Paraneoplastic Diseases

The most common paraneoplastic skin disorders comprise acanthosis nigricans (2), acrokeratosis Bazex (3), erythema gyratum repens (4) (Fig. 1), necrolytic migratory erythema (5), acquired hypertrichosis lanuginosa (6), and the Leser-Trelat sign (7).

These paraneoplastic dermatoses are mostly associated with solid tumors, in particular those involving visceral organs such as the lung and gastrointestinal system. Only rarely, do these dermatoses indicate the presence of nodal or primary cutaneous lymphomas. The sudden appearance of seborrheic keratoses known as Leser-Trelat sign and acanthosis nigricans are so far the only ones reported to arise in primary cutaneous lymphomas such as MF and Sezary syndrome (SS). In contrast, acrokeratosis Bazex, erythema gyratum repens, and necrolytic migratory erythema have not yet been observed in patients with primary cutaneous lymphomas. Two cases have been described in which pityriasis lichenoides chronica (PLC) preceded the occurrence of a medium or large-cell pleomorphic CD30-nega-tive T-cell lymphoma of the skin (8). Recently, we reported for the first time a patient with MF and PLEVA (Fig. 2) (23).

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

Get My Free Ebook


Post a comment