Classification

WHO/EORTC Classification (2005): Not listed WHO Classification (2001): Not listed REAL Classification (1997): Not listed EORTC Classification (1997): Not listed

Exclusive involvement of subcutaneous tissue is the hallmark of subcutaneous panniculitis-like T-cell lymphoma. Primary cutaneous B-cell lymphomas (CBCL) sometimes show involvement of the subcutis but cases where the neoplastic infiltrate is confined to the adipose tissue are extremely rare. We have seen this phenomenon in a case of subcutaneous follicle center cell lymphoma (FCCL) (1). The tumor showed no differences from other primary cutaneous FCCL in regard to its morphology (except the peculiar location of the infiltrate), clinical behavior, and prognosis. A 54-year-old woman presented with a large deep-seated subcutaneous tumor on the scalp. Histologically, a dense infiltrate with a follicular growth pattern confined to the fat tissue with involvement of the underlying galea was seen (Fig. 1). The overlying dermis and epidermis were spared. Surgical removal of the tumor combined with orthovolt radiotherapy resulted in complete remission. Subsequently, a second case of primary subcutaneous FCCL has been identified (H. Kutzner, unpublished data). In addition, a case of primary cutaneous diffuse large B-cell lymphoma associated with the involvement of the subcutis, muscle tissue, and cranial nerves has been described (2).

Figure 1 Dense diffuse lymphocytic infiltrate with a follicular growth pattern in the subcutis.

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