Clinical Parameters
The most important clinical parameter is the stage of the disease, as discussed in Chapter 11 (1,2). TNM stages 1 and 2 do much better than stages with erythroderma or extracutaneous involvement stages 3 and 4.
Other prognostic parameters are ulceration of tumors (3), bone marrow involvement (4), size of atypical circulating cells (<11 nm, >11 nm) (5), and percentage of T cells in the peripheral blood (more or less than 55%) (6). Detection of a peripheral blood T-cell clone seems to be an independent prognostic marker in mycosis fungoides (7).
Demographic factors
Race
Occupation in manufacturing industry
Clinical parameters T-stages
Percentage of skin involvement
Ulceration of skin lesions
Involvement of lymph nodes and visceral organs
Bone marrow involvement
Peripheral blood involvement
Size of atypical circulating cells (nm)
Percentage of T cells in the peripheral blood
Oral manifestation
Histopathology
Cytomorphology
Nuclear volume (nm3)
Large cell lymphoma (LCL)
Cytological transformation
Tumor thickness
Granulomatous features
Hemophagocytosis
DNA cytophotometry
Immunophenotype
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