Since the phenotype of tumor cells has been linked to aggressiveness of the disease, immunophenotyping has both therapeutic and prognostic implications. Alpha=beta expressing forms can be distinguished from gamma/delta positive forms. Due to their aggressive course, SPTCL expressing a gamma/delta phenotype belong to the group of cutaneous gamma/delta lymphoma in the WHO-EORTC classification. Cases with dermal involvement on the first biopsy may give rise to difficulties in classification. In cases where dermal involvement is prominent, it has been recommended to classify such cases as peripheral T-cell lymphoma (pleomorphic or unspecified). Correlation with clinical features is essential for further differentiation. On rare occasion, primary subcutaneous B-cell lymphoma may be found, expanding the spectrum of primary subcutaneous lymphomas (14).
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