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Several theories exist regarding the origin of indeterminate cells. Some authors believe that indeterminate cells may represent precursors of Langerhans cells that acquire Birbeck granules as they transit from dermal to epidermal sites as a result of the interaction of their receptors and epidermis-specific ligands (8). More recently it has been suggested that indeterminate cells represent members of the epidermal/dermal dendritic (antigen-presenting) cell system that are on their way from the skin to the regional lymph nodes (9). According to this concept, indeterminate cell histiocytosis can be regarded as a disorder of proliferating indeterminate cells that have been locally arrested before leaving the skin and traveling as veiled cells via the lymphatics to the T-cell-dependent paracortical areas of the regional lymph nodes (4).

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