Department of Dermatology, University Hospital, Zurich, Switzerland
Cutaneous lymphoma (CL) in most cases is in the end stage of a stepwise pathogenetic process that originates from a reactive inflammatory chronic stimulation of lymphocytes and dendritic cells. Through the accumulation of mutations in genes that regulate the cell cycle, in oncogenes and in suppressor genes, this inflammatory process transforms into malignant lymphoma.
Research on this complex and vexing disease process has, over the years, resulted in many concepts and misconceptions with regard to various issues: classification and prognostic grading, nomenclature and semantics, diagnostic procedures, pathogenesis and management. Some of these issues will be tackled here.
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