Cutaneous Bcell Lymphomas

31. Primary Cutaneous Marginal Zone B-cell Lymphoma 231

Werner Kempf, Dmitry V. Kazakov, and Günter Burg

Classification 231

Definition 231

Clinical Features 231

Histology 232

Immunohistochemistry 233

Molecular Biology 233

Treatment 234

Clinical Course and Prognosis 234

Differential Diagnosis 234

31.1. Immunocytoma 237

Günter Burg and Werner Kempf

Classification 237

Definition 237

Clinical Features 237

Histology 237

Immunohistochemistry 239

Molecular Biology 239

Treatment 239

Clinical Course and Prognosis 240

Differential Diagnosis 240

31.2. Primary Cutaneous Plasmacytoma (PCP) 243

Dmitry V. Kazakov, Günter Burg, and Werner Kempf

Classification 243

Definition 243

Clinical Features 243

Histology 245

Immunohistochemistry 245

Molecular Biology 245

Treatment 245

Clinical Course and Prognosis 245

Differential Diagnosis 246

Comments 246

31.3. Cutaneous Follicular Lymphoid Hyperplasia with Monotypic Plasma Cells 249

Dmitry V. Kazakov, Günter Burg, and Werner Kempf

Definition 249

Clinical Features 249

Histology 249

Immunohistochemistry 250

Molecular Biology 250

Treatment 250

Clinical Course and Prognosis 250

Differential Diagnosis 250

Comments 251

32. Primary Cutaneous Follicle Center Lymphoma 253

Dmitry V. Kazakov, Werner Kempf, and Günter Burg

Classification 253

Definition 253

Clinical Features 253

Histology 253

Immunohistochemistry 255

Treatment 255

Clinical Course and Prognosis 256

Differential Diagnosis 256

Comments 256

33. Primary Cutaneous Diffuse Large B-cell Lymphoma 259

Günter Burg and Werner Kempf

Classification 259

Definition 259

33.1. Primary Cutaneous Large B-cell Lymphoma, Leg Type 259

Other Primary Cutaneous Large B-cell Lymphoma 263

33.2. Primary Cutaneous Diffuse Large B-cell Lymphomas, Other: T-cell-Rich

B-cell Lymphoma 265

Dmitry V. Kazakov, Günter Burg, and Werner Kempf

Classification 265

Definition 265

Clinical Features 265

Histology 266

Immunohistochemistry 266

Molecular Biology 267

Treatment 267

Clinical Course and Prognosis 268

Differential Diagnosis 268

Comments 268

34. Intravascular Large B-cell Lymphoma 269

Günter Burg, Werner Kempf, and Dmitry V. Kazakov

Classification 269

Definition 269

Clinical Features 269

Histology 270

Immunohistochemistry 270

Molecular Biology 271

Therapy 271

Clinical Course and Prognosis 271

Differential Diagnosis 271

Comments 272

35. B-cell Lymphomas with Common Secondary Cutaneous Involvement 275

Günter Burg and Werner Kempf

35.1. Lymphomatoid Granulomatosis 275

Classification 275

Definition 275

Clinical Features 275

Histology 276

Immunohistochemistry 276

Molecular Biology 276

Treatment 276

Clinical Course and Prognosis 276

Differential Diagnosis 277

35.2. Burkitt Lymphoma 279

Günter Burg, Werner Kempf, and Dmitry V. Kazakov

Classification 279

Definition 279

Clinical Features 279

Histology 280

Immunohistochemistry 281

Molecular Biology 281

Treatment 282

Clinical Course and Prognosis 282

Differential Diagnosis 282

Comments 282

35.3. Mantle Cell Lymphoma 285

Christian A. Sander and Michael J. Flaig

Classification 285

Definition 285

Clinical Features 285

Histology 285

Immunohistochemistry 286

Molecular Biology 286

Treatment 286

Clinical Course and Prognosis 287

Differential Diagnosis 287

35.4. Waldenstrom Macroglobulinemia 289

Dmitry V. Kazakov, Günter Burg, and Werner Kempf

Classification 289

Definition 289

Clinical Features 289

Histology 290

Immunohistochemistry 290

Molecular Biology 290

Treatment 291

Clinical Course and Prognosis 291

Differential Diagnosis 291

Comments 291

36. Other Forms of Cutaneous B-cell Lymphomas 293

Dmitry V. Kazakov, Günter Burg, and Werner Kempf

36.1. Subcutaneous B-cell Lymphoma 293

Classification 293

36.2. Cutaneous B-cell Lymphoma with Signet Ring-Cell Morphology 295

Dmitry V. Kazakov, Günter Burg, and Werner Kempf

Classification 295

Definition 295

Clinical Features 295

Histology 295

Immunohistochemistry 296

Molecular Biology 296

Treatment 296

Differential Diagnosis 296

Comments 296

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