Clinically, the differential diagnosis includes solitary lesions of psoriasis, Bowen disease, or circumscribed forms of chronic dermatitis. Although unilesional MF and PR share common clinical and histologic features, PR is distinguished histolo-
Solitary sharply demarcated plaque Histological features
Prominent epidermotropism of lymphocytes with clear cytoplasm Immunophenotype
CD2+, CD3+, CD5+, CD4+, CD45RO+, CD8-, CD30-/+ Some cases: CD8+ or TCRgamma/delta+ Molecular biology
Excision or ionizing radiation Clinical course and prognosis Excellent gically from MF by the presence of marked hyperkeratosis, prominent pagetoid epidermotropism of somewhat larger cerebriform cells and paucicellular dermal infiltrate lacking eosinophils (11,17). Histologically, superficial spreading melanoma and Paget disease may mimic PR, but can readily be distinguished by cytomorphologic and immunophenotypic features (S-100; CEA; EMA) (18,19).
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.