The most important differential diagnosis is reactive (benign) angioendotheliomato-sis, which shares similar histological and ultrastructural features but is clinically distinct from its neoplastic counterpart (2,3). The reactive variant has been associated with subacute bacterial endocarditis, peripheral vascular atherosclerosis, dermal amyloid angiopathy, antiphospholipid syndrome, iatrogenic arteriovenous
Intravascular large B-cell lymphoma
Erythematous or violaceous plaques or nodules on the face, trunk, or lower extremities
Livedo racemosa or erythema nodosum-like features Neurologic signs and symptoms Histological features
Small dermal vessels filled by large lymphocytes Immunophenotype
CD20+, CD23-, and cyclin D1-Some cases CD5+ Rare T-cell cases (CD3+) Molecular biology
Multiagent chemotherapy Clinical course and prognosis Poor prognosis fistulas underlying hepatopathy and hypertensive portal gastropathy, and in chronic lymphatic leukemia.
Erythema nodosum may be a clinical differential diagnosis in some cases of IV-BCL (6). Reactive and neoplastic angioendotheliomatosis show some differences in the immunocytochemical pattern using antibodies to leukocyte common antigen (LCA), specialized B- and T-lymphocytic determinants, Factor VIII-related antigen (FVIIIRAG), blood group isoantigens A, B, and H, epithelial antigens, vimentin, and actin, and Ulex europaeus I lectin (20).
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Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.