Electron Microscopy

The histiocytes contain dense bodies, coated vesicles, myeloid bodies, fat droplets, and dilated rough endoplasmic reticulum filled with granular material. Intra- and

Figure 3 Multicentric reticulohistiocytosis: histiocytes with ground-glass cytoplasm and multiple irregularly distributed nuclei in giant cells. (Specimen courtesy of W. Burgdorf.)

extracytoplasmic type IV collagen inclusions similar to those seen in lymphohistio-cytic neoplasms have been detected.

Multicentric reticulohistiocytosis

Clinical features

Adults, mainly women

Symmetrical, chronic, destructive polyarthritis Acral red-brown or yellow papules or nodules Associated internal malignancy or connective tissue disease possible Histological features

Mono- and multinucleated histiocytes with "ground-glass" cytoplasm, lymphocytes, neutrophils, plasma cells, and eosinophils Immunophenotype

No standardized therapy Clinical course and prognosis Gradual loss of activity in 7-8 years Depends on systemic findings

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