Hairy Cell Leukemia HCL

Stanislaw Buechner

Department of Dermatology, University of Basel, Basel, Switzerland Daniel W.P. Su

Department of Dermatology, Mayo Clinic, Rochester, Minnesota, U.S.A.

Hairy-cell leukemia (HCL) is a rare chronic lymphoproliferative disorder characterized by the presence of circulating monoclonal B lymphocytes that have prominent cytoplasmic projections. Hairy-cell leukemia accounts for 2-3% of all adult leuke-mias. There is a 4:1 male to female predominance with the median age at presentation being 52 years. Hairy cells are slightly larger than regular lymphocytes and show distinct round-to-oval nuclei that are centrally placed within a pale staining cytoplasm with multiple hair-like projections.

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