Histology

The infiltrates present a typical B-cell pattern with well-circumscribed nodules in the dermis extending in some instances into the subcutaneous tissue (Fig. 3). The epidermis is not involved. The predominant cells are small well-differentiated lymphocytes,

Acrodermatitis Chronica Atrophicans

Figure 2 Similar lesion on the background of acrodermatitis chronica atrophicans.

Figure 3 Dense diffuse infiltrate without formation of germinal centers.
Conteo Plaquetas
Figure 4 Plasmacytoid differentiated cells, some of which exhibit intranuclear inclusions (Dutcher bodies) (PAS staining). (Kindly provided by H. Kerl.)

lymphoplasmocytoid cells, and mature plasma cells. Intranuclear (Dutcher bodies) and intracytoplasmatic PAS-positive globular inclusions, representing immunoglobulin deposits, are common (Fig. 4). These features can also be found in other B-cell lymphomas, particularly B-cell chronic lymphocytic leukemia, marginal zone and follicle center cell lymphomas, and therefore cannot be regarded as specific for immunocytoma even though they are very typical.

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