The infiltrates present a typical B-cell pattern with well-circumscribed nodules in the dermis extending in some instances into the subcutaneous tissue (Fig. 3). The epidermis is not involved. The predominant cells are small well-differentiated lymphocytes,
Figure 2 Similar lesion on the background of acrodermatitis chronica atrophicans.
lymphoplasmocytoid cells, and mature plasma cells. Intranuclear (Dutcher bodies) and intracytoplasmatic PAS-positive globular inclusions, representing immunoglobulin deposits, are common (Fig. 4). These features can also be found in other B-cell lymphomas, particularly B-cell chronic lymphocytic leukemia, marginal zone and follicle center cell lymphomas, and therefore cannot be regarded as specific for immunocytoma even though they are very typical.
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