Histology

The histopathologic hallmark of this type of CTCL is the subcutaneous localization and growth pattern of usually nonepidermotropic, focal infiltrates simulating lobular

Figure 1 Subcutaneous panniculitis-like T-cell lymphoma: infiltrated subcutaneous nodules with ulceration on the leg.

panniculitis (2,3) (Fig. 2). Karyorrhexis and fat necrosis are prominent features. The tumor cells are lymphoid cells of varying size, often with chromatin-dense nuclei. Rimming of adipocytes by tumor cells is a common, but not specific, finding for SPCTL (Fig. 3). Many histiocytes are found and erythrophagocytosis can be present. Since the lymphoproliferative process is focal, large and deep biopsies are mandatory to establish diagnosis. During evolution, the dermis may become involved by tumoral infiltrates, especially in cases with g/d+/CD56+ phenotype (5).

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