Immunohistochemistry

The tumor cells have a CD3+ CD4+ T helper phenotype CD3+ CD8+ similar cases were reported (2). Loss of T-cell antigens has been observed. Tumor cells are nega-

Figure 2 CD30-negative small to medium-sized pleomorphic lymphoma: diffuse infiltrate of small to medium-sized lymphocytes with convoluted nuclei and abundant cytoplasm. Prominent endothelial cells.

tive for CD30. The CD20+ B-cells may be admixed and account for up to 20% of the infiltrate (3).

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