The large neoplastic cells express pan-B-cell antigens CD20 and CD79a, but are negative for CD15 and CD30 (Fig. 3). Light chain restriction is usually found.

Figure 2 Large blasts representing B cells surrounded by small T lymphocytes.
Figure 3 Scattered CD20-positive B cells (red color) in the background of T-cells.

The reactive small cell population represents T-helper cells but small reactive B cells can also be found (6).

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