Skin atrophy, transient serum

Cortisol level depression Allergic dermatitis (aqueous-based drug), non-melanoma skin cancer Residual telangectasias, myelosuppression Local irritation

Burning, non-melanoma skin cancer Burning, nausea, accelerated photoaging, non-melanoma skin cancer Sepsis, fever, transient hypotension

Flulike syndrome, asthenia, leukopenia, depression, thyroid dysfunction Flulike syndrome, asthenia, leukopenia

DFS = 7.3 years. Useful in maintenance therapy 64 in Tl; 92 in T2


DFS = 43 months

Controversial data


Isotretinoin, etretinate, x x


Oral bexarotene x x

Cytokines Interleukin-2 x

Interleukin-12 x


Single agent x

Methotrexate x

Gemcitabine x

Pentostatin x

Fludarabine x

Cladribine x

Pegylated liposomal x Doxorubicin

Combined x

68 44-50

84 48

7 72

34 56

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