Introduction

The topic of true histiocytic malignancies is complex and controversial for many reasons. First, these disorders are very rare. Second, the criteria applied in the past to categorize a neoplasm as a ''malignant histiocytic tumor'' differ from those used today. Many previously published cases that were reassessed after the introduction of immunohistochemistry lacked convincing evidence for a histiocytic origin of the neoplastic cells and most turned out to be lymphoproliferative disorders. In addition, the older literature is replete with terms such as "histiocytic medullary reticulosis," "malignant histiocytosis,'' "true histiocytic lymphoma," "true histiocytic lympho-ma/sarcoma," and "monocytic sarcoma.'' This terminology makes the comparison of various entities very difficult (1,2).

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