Clonal T-cell populations have been found in inflammatory skin diseases such as lichen planus and psoriasis. Preferential usage of V beta 3 and/or V beta 13.1 genes by the lesional CD8+ T cells has been found in psoriatic lesions (5). Various clones of T cells have been isolated from mucosal lichen planus (6). Preferential use of V alpha 2 and V beta 3 of TCR was found on lymphocytes in mucosal lichen planus, whereas T-cells in Candida-induced lesions did not show a restricted TCR pattern (7). These data reflect the dominance of certain clones in the infiltrating T cells of lichen planus and psoriasis.
Was this article helpful?
Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.