Molecular Biology

T-cell clones in the skin or peripheral blood have been detected by Southern blot in 40 up to 87% and by PCR in 90% of cases. These clones can also be present in peripheral blood of healthy elderly people. Peripheral blood T-cell clones not related to the tumor cell clone have been found in patients with nonerythrodermic CTCL. Allelotyping studies revealed allelic loss in 67% of patients with SS. High rates of loss of heterozygosity were detected on 9p (46%) and 17p (42%) with lower rates on 2p (12%), 6q (7%), and 10q (12%) (19).

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