Molecular Biology

Immunoglobulin heavy and light chain genes are clonally rearranged. Translocation of t(9;14) gene has been reported in nodal immunocytomas (5). The Bcl-2 oncogene, normally involved in nodal follicular or follicle center lymphomas, is in germ-line configuration in cutaneous immunocytoma. In MALT lymphomas, the etiologic role of Helicobacter pylori is well established: induction of reactive lymphoid hyperplasia may be followed by transformation into malignant B-cell lymphoma. Borrelia burgdorferi has been pathogenetically implicated in cutaneous B-cell pseudolymphomas and B-cell lymphomas (6-8), including immunocytoma (1).

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