Molecular Biology

Various cytogenetic abnormalities in B-LBL have been described and are of prognostic importance. The translocation t(9;22) is more frequent in adults and associated with a poorer prognosis.

Precursor B-cell lymphoblastic lymphoma/leukemia

Clinical features Children and young adults. Multiple reddish nodules. Ulceration uncommon Histological features

Nodular or diffuse monomorphous infiltrates of lymphoblasts with "starry sky'' Immunophenotype

CD19+, CD20-, CD79a+, CD99+, TdT+ Molecular biology

Translocation t(9;22) in some cases Treatment

Chemotherapy Clinical course and prognosis Variable prognosis, Good prognosis, especially in children. Tendency to relapse.

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