Formulations

The absorption of glycolic acid in human skin is pH-, strength- and time-dependent. Seventy percent glycolic acid solutions are commonly used as superficial chemical peeling agents, the pH of these solutions ranges from 0.08 to 2.75. Peeling solutions with a pH below 2 have dem-2 onstrated the potential to induce crusting and necrosis, which has not been seen with the partially neutralized solutions with a pH above 2 [4]. The higher concentration acid (70%) created more tissue damage than the lower concentration (50%) compared to solutions with free acid. An increase of transmembrane permeability coefficient is observed with a decrease in pH, providing a possible explanation for the effectiveness of glycolic acid in skin treatment.

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