Individual patient data

The main aims of data checking procedures are to ensure the accuracy of data, integrity of randomization and completeness of follow up. For any one trial the results of all the data checks should be considered together to build up an overall picture of that trial and any associated problems. Where there are concerns about the data supplied, these should be brought to the attention of the trialist and sympathetic efforts made to resolve them. Range and consistency checks should be carried out...

Example of an IPD metaanalysis Postoperative radiotherapy in nonsmallcell lung cancer

Introduction Worldwide, over half a million new cases of lung cancer are diagnosed each year 58 and it is the leading cause of cancer deaths. Surgery is the treatment of choice for non-small-cell lung cancer (NSCLC), and around one fifth of tumours are suitable for potentially curative resection 59 . However, even for patients with apparently completely resected disease, survival rates are disappointing - around 40 per cent at two years. In an effort to improve both local control and survival,...