We much appreciated the help and encouragement we received from Ian Chalmers of the UK Cochrane Centre, Mike Clarke of the UK Cochrane Centre, Bec Hanley (formerly) of the consumers in NHS research support unit, Joe Pater of the National Cancer Institute of Canada, and Catherine Barnes of Oxford University Press. We are also very grateful to many people in the MRC Clinical Trials Unit, especially the following, for their help, advice and comments on draft, which were greatly appreciated: Sam Bottomley, Sarah Burdett, Pat Cook, Janet Darbyshire, Gareth Griffiths, Linda Jenkin, Andrew Lewin, Laryssa Rydewska, Jayne Tierney, Barbara Uscinska, and Claire Vale.

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