Box 44 Supplementary notes on eligibility in the AXIS colorectal cancer trial

Contraindications are specified not by the protocol but by the responsible clinician and might include:

♦ Intra-abdominal sepsis

♦ Insulin-dependent diabetes

♦ Marked hepatic impairment

♦ Major life-threatening disease other than colorectal cancer death. However, continuous variables such as age can never be dichotomized in a way which precisely defines fit and unfit, and other measures of 'fitness' are probably more appropriate.

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