Running trials requires excellent communication between the trial coordinators and collaborators. In addition to good telephone, voice-mail, facsimile (fax) and e-mail facilities, there should preferably be a telephone line dedicated to randomization. Randomizations should also be acceptable by fax and e-mail, and a number of groups can now accept 24-hour interactive randomizations through the Internet or on touch-tone telephone systems. This facility may be particularly useful for international trials, but security and confidentiality need to be assured. Some offices provide 24-hour manned telephone lines for randomization.

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