In this book, we have described the conduct of cancer clinical trials, systematic reviews and meta-analyses. Some trials will be conducted by a single centre or small group of collaborating hospitals with a separate grant for each study, others as part ofa long-term programme of research by an established trials centre and research group with some core funding. In this final chapter, we describe the advantages of such an established group. These include the strategic planning of coherent programmes of clinical studies and meta-analyses; undertaking large multi-centre and multi-group trials nationally and internationally; having a team of well-trained and experienced core staff thoroughly familiar with locally developed and well tested procedures, who have built up a group of centres conversant with the practicalities of collaborating in trials over many years; developing long-term collaboration with patient-advocacy groups; training and teaching; fulfilling advisory and consultative roles, and conducting a programme of trials-associated and methodological research.

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