Manual implementation

A practical method to implement minimization manually is through the use of a series of cards, one for each level of each minimization factor, as shown in Fig. 4.8. Each card is divided vertically into columns, the number equalling the number of treatments. The first patients must be randomized using a list prepared using simple randomization (Section 4.7.2). A patient ID number is written on to the cards which correspond to the patient's characteristics, in the appropriate column. Thereafter, as each new patient is entered, take out the cards corresponding to their characteristics, sum the number of patients in each treatment column across all the cards, allocate the patient to the treatment with the smallest number and write their ID in the appropriate places. If at any stage the treatment allocations are balanced, then allocate the treatment at random (using pre-prepared randomly generated lists for example).

0 0

Post a comment