Problems with the conventional order of events

Studies have shown that the proportion of patients entering cancer clinical trials is generally low - a few per cent - with the exception of those treated in specialist centres. Different studies reveal different reasons for this, and perhaps the most common is simply that patients are not asked (see Chapter 2). However, a recurring, and understandable reason, is that patients refuse consent. In an effort to limit the impact of patient refusal, an alternative randomization design was introduced by Zelen who had considered whether there might be alternative, ethical designs which could increase the number of patients going into trials.

0 0

Post a comment