Unequal allocation

As for the other methods ofrandomization, unequal treatment allocation can be accommodated. For example, suppose we wished to allocate two out of every five patients to treatment A and three out of every five patients to treatment B. Work through the procedure as above until the totals for each treatment allocation are obtained. Then, multiply the treatment A total by three and the treatment B total by two (if the allocations to date are in perfect balance the resulting numbers will be equal). Treatment allocation can then proceed as before, assigning the new patient to the treatment with the lowest (adjusted) total score, or allocating at random if the adjusted totals are balanced.

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