Nicotine

Nicotine is an alkaloid found in tobacco, and is responsible for its pharmacological effects and addiction. Contact dermatitis from nicotine, considered as rare, has been more frequent since its use in transdermal systems. Irritant dermatitis is mainly encountered, as contact urticaria seems to be rare. Allergic contact dermatitis, sometimes generalized, has been reported, with positive patch testing to nicotine base (10 ethanol or petrolatum). No consequences have been reported in patients who...

Zinc Pyrithione Zinc Omadine

CAS Registry Number 13463-41-7 and more than 20 others The sodium salt of N-hydroxy-2-pyridinethiones has germicidal activity against yeasts and fungi. Sodium omadine is a 40 aqueous solution of sodium pyrithione. It is used in the metallurgical industry as a component of water-based metalworking fluids, of aceto-polyvinyl lattices, water-based printer's ink, a lubricant for synthetic fibers and anti-dandruff shampoos. Zinc pyrithione is widely used in anti-dandruff shampoos and is a classic...

With the Patients Own Products

Frosch, Johannes Geier, Wolfgang Uter, An Goossens Commercially available patch test kits (standard series and various supplementary series) are the basis of a diagnostic work-up if an allergic contact dermatitis is to be confirmed. However, various investigators have shown that this way of testing is not sufficient. Menn et al. 20 found in a multicenter study that the European Standard Series detects only 37-73 of the responsible allergens in patients with contact dermatitis. The...

Vitamin E Acetate dlVitamin E Acetate d

CAS Registry Number 7695-91-2 , CAS Registry Number 58-95-7 Tocopherol and tocopheryl acetate are used mainly as antioxidants. Tocopheryl acetate, an ester of tocopherol (vitamin E), can induce allergic contact dermatitis. De Groot AC, Berretty PJ, van Ginkel CJ, den Hengst CW, van Ulsen J, Weyland JW (1991) Allergic contact dermatitis from tocopheryl acetate in cosmetic creams. Contact Dermatitis 25 302-304 Matsumura T, Nakada T, Iijima M (2004) Widespread contact dermatitis from tocopherol...

Usnic Acid dUsnic Acid lUsnic Acid

CAS Registry Number 125-46-2 (CAS Registry Number 7562-61-0 , CAS Registry Number 6159-66-6 ) Usnic acid is a component of lichens, also used as a topical antibiotic. Allergic contact dermatitis from lichens occurs mainly occupa-tionally in forestry and horticultural workers, and in lichen pickers. Aalto-Korte K, Lauerma A, Alanko K (2005) Occupational allergic contact dermatitis from lichens in present-day Finland. Contact Dermatitis 52 36-38 Hahn M, Lischka G, Pfeifle J, Wirth V (1995) A case...

Toluene25Diamine

P-Toluylenediamine, p-Toluenediamine Toluene-2,5-diamine is a permanent hair dye involved in contact dermatitis in hairdressers and consumers. It does not cross-react with PPD, but co-sensitization is frequent. Frosch PJ, Burrows D, Camarasa JG, Dooms-Goossens A, Ducombs G, Lahti A, Menne T, Rycroft RJG, Shaw S, White IR, Wilkinson JD (1993) Allergic reactions to a hairdresser's series results from 9 European centres. Contact Dermatitis 28 180-183 Guerra L, Tosti A, Bardazzi F, Pigatto P, Lisi...

Sodium Pyrosulfite Disodium Disulfite E223 CAS Registry Number [7681574O O

This agent is frequently used as a preservative in pharmaceutical products, in the bread-making industry as an antioxidant, and it can induce contact dermatitis. It can be used as a reducing agent in photography and caused dermatitis in a photographic technician, probably acting as an aggravating irritative factor. Sodium metabisulfite contains a certain amount of sodium sulfite and sodium sulfate. Acciai MC, Brusi C, Francalanci Giorgini S, Sertoli A (1993) Allergic contact dermatitis in...

Ranitidine

Ranitidine Hydrochloride CAS Registry Number 66357-59-3 Ranitidine, an H2-receptor antagonist, can cause contact dermatitis within the pharmaceutical industry and in healthcare workers, or may induce systemic drug reactions in patients. Martinez MB, Salvador JF, Aguilera GV, Mas IB, Ramirez JC (2003) Acute generalized exanthematous pustulosis induced by ranitidine hydrochloride. Contact Dermatitis 49 47 Romaguerra C, Grimalt F, Vilaplana J (1988) Epidemic of occupational contact dermatitis from...

PVPHexadecene Copolymer

PVP hexadecene copolymer, another PVP copolymer used for identical applications as PVP eicosene copolymer, has been rarely implicated in contact dermatitis. De Groot AC, Bruynzeel DP, Bos JD, van der Meeren HL, van Joost T, Jagtman BA, Weyland JW (1988) The allergens in cosmetics. Arch Dermatol 124 1525-1529 Scheman A, Cummins R (1998) Contact allergy to PVP hexadecene copolymer. Contact Dermatitis 39 201

Propyl Gallate

This gallate ester (E 311) is an antioxidant frequently used in the food, cosmetic, and pharmaceutical industries to prevent the oxidation of unsaturated fatty acids into rancid-smelling compounds. It causes cosmetic dermatitis mainly from lipsticks and induced contact dermatitis in a baker, and in a female confectioner, primarily sensitized by her night cream, who fried doughnuts -the margarine probably containing gallates. Bojs G, Niklasson B, Svensson A (1987) Allergic contact dermatitis to...

Propranolol

Propranolol is a beta-blocking agent that was responsible for the sensitization of workers in drug synthesis. In one case, epichlor-hydrin was used for the production of drugs propranolol and oxprenolol. Cross-reactivity is expected between beta-blockers. Pereira F, Dias M, Pacheco FA (1996) Occupational contact dermatitis from propranolol, hydralazine and bendroflumethiazide. Contact Dermatitis 35 303-304 Rebandel P, Rudzki E (1990) Dermatitis caused by epichlorhydrin, Oxprenolol hydrochloride...

Prilocaine Hydrochloride

CAS Registry Number 25655-41-8 (CAS Registry Number 1786-81-8 ) Prilocaine in a local anesthetic of the amide group. It can induce allergic contact dermatitis, particularly from EMLA cream. Le Coz CJ, Cribier BJ, Heid E (1996) Patch testing in suspected allergic contact dermatitis due to Emla cream in haemodialyzed patients. Contact Dermatitis 35 316-317

Parthenolide

Parthenolide is a sesquiterpene lactone found Asteraceae-Com-positae such as feverfew (Tanacetum parthenium Schultz-Bip.) or congress grass (Parthenium hysterophorus L.). Hausen BM, Osmundsen PE (1983) Contact allergy to parthenolide in Tanacetum parthenium (L.) Schultz-Bip. (feverfew, Asteraceae) and cross-reactions to related sesquiterpene lactone containing Compositae spe-cies.Acta Derm Venereol (Stockh) 63 308-314 Lamminpaa A, Estlander T, Jolanki R, Kanerva L (1996) Occupational allergic...

ONitrop Phenylenediamine Onpd Ci 76070 CAS Registry Number [5307142 NH2

ONPD is a hair dye and a sensitizer in hairdressers and consumers who are generally sensitive to PPD too. Frosch PJ, Burrows D, Camarasa JG, Dooms-Goossens A, Ducombs G, Lahti A, Menne T, Rycroft RJG, Shaw S, White IR, Wilkinson JD (1993) Allergic reactions to a hairdresser's series results from 9 European centres. Contact Dermatitis 28 180-183 Guerra L, Tosti A, Bardazzi F, Pigatto P, Lisi P, Santucci B, Valsecchi R, Schena D,Angelini G, Sertoli A,Ayala F, Kokelj F (1992) Contact dermatitis in...

Oh

As a fragrance allergen, anisyl alcohol has to be mentioned by name in cosmetics within the EU. Budavari S, O'Neil MJ, Smith A, Heckelman PE, Kinneary JF (eds) (1996) The Merck Index, 12th edn. Merck, Whitehouse Station, N.J., USA CAS Registry Number 1309-64-4 Sb203 This hard shiny metal is often alloyed to other elements. It is used in various industrial fields such as batteries, printing machines, bearing, textile, and ceramics. It caused positive patch test reactions in two workers in the...

Oh Oh

Chlorhexidine is a broad-spectrum antimicrobial agent, a synthetic biguanide antiseptic and disinfectant, available under different forms (diacetate, dihydrochloride, and mostly digluconate). It is also used as a biocide in several topicals and cosmetics. It may cause allergic contact dermatitis, photosensitivity or even fixed drug eruption, mainly after prolonged and repeated applications in health workers, leg ulcer, and leg eczema patients. Immediate-type reactions have been reported contact...

O

Kanerva L, Estlander T, Jolanki R, Tarvainen K (1993) Occupational allergic contact dermatitis caused by exposure to acrylates during work with dental prostheses. Contact Dermatitis 28 268-275 Kanerva L, Lauerma A, Estlander T, Alanko K, Henriks-Eckerman ML, Jolanki R (1996) Occupational allergic contact dermatitis caused by photobonded sculptured nails and a review of (meth) acrylates in nail cosmetics. Am J Contact Dermat 7 109-115 Kiec-Swierczynska MK (1996) Occupational allergic contact...

O 1 1 1 T ys df

Imidazolidinyl urea, a formaldehyde releaser related to diazol-idinyl urea (see above), is used as an antimicrobial agent very active against Gram-positive and Gram-negative bacteria, used as a synergist in combination with parabens. It is used as a preservative in aqueous products, mainly in cosmetics, toiletries, and liquid soaps. Karlberg AT, Skare L, Lindberg I,Nyhammar E (1998) A method for quantification of formaldehyde in the presence of formaldehyde donors in skin-care products. Contact...

NPhenyl2Naphthylamine Neozone

CAS Registry Numbers 135-88-6 , 52907-17-2 , 84420-28-0 Phenyl-beta-naphthylamine is an amine compound. Sensitization was reported in patients with hypersensitivity from rubber. Conde-Salazar L, Guimaraens D, Romero LV, Gonzalez MA (1987) Unusual allergic contact dermatitis to aromatic amines. Contact Dermatitis 17 42-44 Conde-Salazar L, Del-Rio E, Guimaraens D, Gonzalez Domingo A (1993) Type IV allergy to rubber additives a 10-year study of 686 cases. J Am Acad Dermatol 29 176-180...

Nonylphenol Ethoxylates PEGn Nonyl Phenyl Ether Polyoxyethylene n Nonyl Phenyl Ether

CAS Registry Number 26027-38-3 and more than 25 other numbers CAS Registry Number 26027-38-3 and more than 25 other numbers Their general formula is C9H19C6H4(OCH2CH2)nOH. Each non-oxynol is characterized by the number (n) of ethylene oxide units repeated in the chain for example, nonoxynol-9, nonoxynol-14. They are present in detergents, liquid soaps, emulsifiers for creams, fabric softeners, photographic paper additives, hair dyes, lubricating oils, spermicides, and anti-infective agents....

Methylmorphine

CAS Registry Number 76-57-3 (CAS Registry Number 52-28-8 , CAS Registry Number 1422-07-7 ) Codeine has been reported as an occupational sensitizer in workers in the production of opium alkaloids. Codeine has been responsible for fixed drug eruptions or generalized dermatitis. Cross-sensitivity is expected to morphine. Conde-Salazar L, Guimaraens D, Gonzalez M, Fuente C (1991) Occupational allergic contact dermatitis from opium alkaloids. Contact Dermatitis 25 202-203 Estrada JL, Alvarez Puebla...

MethamNa Carbathion SodiumNMethyldithiocarbamate

Metham-Na is a fungicide nematocide of the dithiocarbamate group. Sensitization occurs among agricultural workers. Koch P (1996) Occupational allergic contact dermatitis and airborne contact dermatitis from 5 fungicides in a vineyard worker. Cross-reactions between fungicides of the dithiocarbamate group Contact Dermatitis Pambor M, Bloch Y (1985) Dimethoat und Dithiocarmabat als berufliche Kontaktallergene bei einer Agrotechnikerin. Dermat Monatsschr 171 401-405 Schubert H (1978) Contact...

Doxepin

This benzoxepin tricylcic drug has antidepressant, anticholin-ergic, anti-itching, and antihistamine properties. After oral use, it has been developed as a topical anti-itching agent. Allergic contact dermatitis is not infrequent. Buckley DA (2000) Contact allergy to doxepin. Contact Dermatitis 43 231-232 Taylor JS, Praditsuwan P, Handel D, Kuffner G (1996) Allergic contact dermatitis from doxepin cream. One-year patch test clinic experience. Arch Dermatol 132 515-518 1-Chloro-2,3-Epoxypropane...

Disperse Blue 106

This clothing dye used in synthetic fibers is one of the most potent sensitizers in clothes. Allergic contact dermatitis is relatively frequent in consumers. Occupational textile dye dermatitis was reported in a ready-to-wear shop. Constant concomitant reactions with Disperse Blue 124 are due to their chemical similarities, as with photograph developers CD1, CD2, CD3, and CD4. Menezes-Brandao F, Altermatt C, Pecegueiro M, Bordalo O, Foussereau J (1985) Contact dermatitis to Disperse Blue 106....

DihydroxyN3Hydroxypropyl33Dimethylbutanamide Pantothenylol NPantoyl3Propanolamine Panthenol Pantothenyl Alcohol

Pan(to)thenol is the alcohol corresponding to pantothenic acid, of the vitamin B5 group. It is used as a food additive, and in skin and hair products as a conditioning agent. Contact dermatitis and urticaria have been reported. Schalock PC, Storrs FJ, Morrison L (2000) Contact urticaria from panthe- nol in hair conditioner. Contact Dermatitis 43 223 Stables GI, Wilkinson SM (1998) Allergic contact dermatitis due to panthenol. Contact Dermatitis 38 236-237

Dibutyl Phthalate

It is mainly used as a nonreactive epoxy diluent. Capon F, Cambie MP, Clinard F, Bernardeau K, Kalis B (1996) Occupational contact dermatitis caused by computer mice. Contact Dermatitis 35 57-58 Chieregato C, Vincenzi C, Guerra L, Farina P (1994) Occupational allergic contact dermatitis due to ethylenediamine dihydrochloride and cresyl glycidyl ether in epoxy resin systems. Contact Dermatitis 30 120

Diallyl Disulfide

Diallyl disulfide is one of the major allergens in garlic (Allium sativum) and onions. Among patients patch-test-positive to garlic, all 13 who were tested had positive reactions to diallyl sulfide 5 pet. Bruynzeel DP (1997) Bulb dermatitis. Dermatological problems in the flower bulb industries. Contact Dermatitis 37 70-77 Lamminpaa A, Estlander T, Jolanki R, Kanerva L (1996) Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 34 330-335 McFadden JP, White...

Cyclohexen1one

This strong sensitizer has been responsible for chemical burning followed by sensitization in a chemistry student. Goossens A, Deschutter A (2003) Acute irritation followed by primary sensitization to 2-cyclohenen-1-one in a chemistry student. Contact Dermatitis 48 163-164 A rubber accelerator chemical. The most frequent occupational categories are metal industry, homemakers, health services and laboratories, and the building industry. Conde-Salazar L, Del-Rio E, Guimaraens D, Gonzalez Domingo...

Cyclohexanone

Used as a polyvinyl chloride solvent, cyclohexanone caused contact dermatitis in a woman manufacturing PVC fluidotherapy bags.Cyclohexanone probably does not cross-react with cyclohexanone resin. A cyclohexanone-derived resin used in paints and varnishes, caused contact dermatitis in painters. Bruze M, Boman A, Bergquist-Karlson A, Bjorkner B, Wahlberg JE, Woog E (1988) Contact allergy to cyclohexanone resin in humans and guinea pigs. Contact Dermatitis 18 46-49 Sanmartin O, de la Cuadra J...

Cooh

Ketoprofen is an anti-inflammatory drug, used both topically and systemically. It is above all a photoallergen, responsible for photo- allergic or photo-worsened contact dermatitis, with sun-induced, progressive, severe, and durable reactions. Recurrent photosensitivity is possible for many years. Photosensitivities are expected to thiophene-phenylketone derivatives such as tiaprofenic acid and suprofen, to ketoprofen esters such as piketoprofen, and to benzo-phenone derivatives (see above)...

Cinnamic Aldehyde Cinnamaldehyde 3Phenyl2Propenal CAS Registry Number [104552

This perfumed molecule is used as a fragrance in perfumes, a flavoring agent in soft drinks, ice creams, dentifrices, pastries, chewing-gum, etc. It can induce both contact urticaria and de-layed-type reactions. It can be responsible for dermatitis in the perfume industry or in food handlers. Cinnamic aldehyde is contained in fragrance mix.As a fragrance allergen, it has to be mentioned by name in cosmetics within the EU. Nethercott JR, Holness DL (1989) Occupational dermatitis in food handlers...

Cincaine Cinchocaine Percaine Sovcaine

CAS Registry Number 85-79-0 (CAS Registry Number 61-12-1 ) Dibucaine hydrochloride is an amide group local anesthetic that can induce allergic contact dermatitis. Erdmann SM, Sachs B, Merk HF (2001) Systemic contact dermatitis from cinchocaine. Contact Dermatitis 44 260-261 Nakada T, Iijima M (2000) Allergic contact dermatitis from dibucaine hydrochloride. Contact Dermatitis 42 283

Captafol

Captafol is a pesticide, belonging to thiophthalimide group. Occupational contact dermatitis was reported in an agricultural worker who had multiple sensitizations. Peluso AM, Tardio M, Adamo F, Venturo N (1991) Multiple sensitization due to bis-dithiocarbamate and thiophthalimide pesticides. Contact Dermatitis 25 327

Caffeic Acid Dimethyl Allylic Ester

3-Methyl-2-Butenyl-Caffeate CAS Registry Number 108084-13-7 This is the major allergen of poplar bud resins and of propolis, the bee glue derived almost exclusively from poplar buds. Lamminpaa A, Estlander T, Jolanki R, Kanerva L (1996) Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 34 330-335 Oliwiecki S, Beck MH, Hausen BM (1992) Occupational contact dermatitis from caffeates in poplar bud resin in a tree surgeon. Contact Dermatitis 27 127-128

BooH

Mezlocillin is an acylaminopenicillin, which caused both immediate and delayed hypersensitivity in a nurse. Keller K, Schwanitz HJ (1992) Combined immediate and delayed hypersensitivity to mezlocillin. Contact Dermatitis 27 348-349 CAS Registry Number 141-43-5 OH Monoethanolamine is contained in many products,such as metal-working fluids. It is mainly an irritant. Traces may exist in other ethanolamine fluids. Bhushan M, Craven NM, Beck MH (1998) Contact allergy to 2-amino-ethanol...

Bardac22

This quaternary ammonium compound is used as a detergent-disinfectant in hospitals, as an algaecide in swimming pools, as a fungicide, and against termites in wood. We recently observed severe contact dermatitis in a slaughterhouse worker using a liquid soap containing this product (personal observation). Dejobert Y, Martin P, Piette F, Thomas P, Bergoend H (1997) Contact dermatitis from didecyldimethylammonium chloride and bis-(amino-propyl)-laurylamine in a detergent-disinfectant used in...

A

This chlorinated and brominated product is employed in agriculture as a fungicide, for wood preservation. When used to sanitize pools and spas, releasing both chlorine and bromine derivatives, it can induce irritant or allergic contact dermatitis. Rycroft RJG, Penny PT (1983) Dermatoses associated with brominated swimming pools. Br Med J (Clin Res Ed) 287 462 Sasseville D, Moreau L (2004) Contact allergy to i-bromo-3chloro-5, 5-dimethylhydantoin in spa water. Contact Dermatitis 50 323-324 (6CI,...

Acrylates And Chalazion

Kanerva L, Lauerma A, Estlander T, Alanko K, Henriks-Eckerman ML, Jolanki R 1996 Occupational allergic contact dermatitis caused by photobonded sculptured nails and a review of meth acrylates in nail cosmetics. Am J Contact Dermat 7 109-115 Kiec-Swierczynska MK 1996 Occupational allergic contact dermatitis due to acrylates in Lodz. Contact Dermatitis 34 419-422 Rustemeyer T, Frosch PJ 1996 Occupational skin diseases in dental laboratory technicians. I . Clinical picture and causative factors....

Polyvinylpyrrolidone Iodine PVPIodine

Povidone-iodine is iodophor, used as a topical antiseptic. A 10 povidone-iodine solution contains 1 available iodine, but free-iodine is at 0.1 concentration. Skin exposure causes irritant rather than allergic contact dermatitis. In such a situation however, iodine seems to be the true hapten. Lachapelle JM 2005 Allergic contact dermatitis from povidone-iodine a re-evaluation study. Contact Dermatitis 52 9-10 Tosti A, Vincenzi C, Bardazzi F, Mariani R 1990 Allergic contact dermatitis due to...

Octocrilene

Octocrylene is an anti-UVB filter used in cosmetics that may induce photoallergic contact dermatitis. Carrotte-Lefebvre I, Bonnevalle A, Segard M, Delaporte E, Thomas P 2003 Contact allergy to octocrylene. Contact Dermatitis 48 46-47 Octyl gallate, a gallate ester E 311 , is an antioxidant added to foods and cosmetics to prevent oxidation of unsaturated fatty acids. Cases were sparsely reported in food industry or from lipsticks. Patch tests are frequently irritant. De Groot AC, Gerkens F 1990...

Cocamide DEA Coconut Oil Fatty Acids Diethanolamide NNbis2Hydroxyethyl Coco Fatty Acid Diethanolamide Cocoyl

Cocamide DEA, manufactured from coconut oil, is widely used in industry and at home as a surface-active agent. It is contained in hand gels, hand washing soaps, shampoos, and dish-washing liquids for its foam-producing and stabilizing properties, and in metalworking fluids and polishing agents as an anticorrosion inhibitor. Fowler JF Jr 1998 Allergy to cocamide DEA.Am J Contact Dermat 9 40-41 Kanerva L, Jolanki R, Estlander T 1993 Dentist's occupational allergic contact dermatitis caused by...

Info

CAS Registry Number 97-54-1 c s-isoeugenol Isoeugenol is a mixture of two cis and trans isomers. It occurs in ylang-ylang and other essential oils. It is a common allergen of perfumes and cosmetics such as deodorants, and is contained in fragrance mix. Its presence in cosmetics is indicated in the INGREDIENTS series. Substitution by esters such as isoeugenyl acetate not indicated on the package does not always resolve the allergenic problem, because of the in vivo hydrolysis of the substitute...

Dictionary of Contact Allergens Chemical Structures Sources and References

Bisphenol Epoxy Diacrylate

Le Coz, Jean-Pierre Lepoittevin This chapter has been written in order to familiarize the reader with the chemical structure of chemicals implicated in contact dermatitis, mainly as haptens responsible for allergic contact dermatitis. For each molecule, the principal name is used for classification. We have also listed the most important synonym s , the Chemical Abstract Service CAS Registry Number that characterizes the substance, and its chemical structure. The reader will find...