Diphencyprone

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2,3-Diphenylcyclopropenone CAS Registry Number [886-38-4]

Diphencyprone is a potent contact allergen used in topical immunotherapy, to treat some severe alopecia areata. It is responsible for occupational contact dermatitis in chemists and dermatology department staff.

Suggested Reading

Sansom JE, Molloy KC, Lovell CR (1995) Occupational sensitization to diphencyprone in a chemist. Contact Dermatitis 32:363 Temesvári E, González R, Marschalkó M, Horváth A (2004) Age dependence of diphenylcyclopropenone sensitization in patients with alopecia areata. Contact Dermatitis 50:381-382

A rubber accelerant, formerly contained in "black-rubber mix." The most frequent occupational categories are in the metal industry, homemakers, health services and laboratories, and the building industry.

Suggested Reading

Condé-Salazar L, Del-Rio E, Guimaraens D, Gonzalez Domingo A (1993) Type IV allergy to rubber additives: a 10-year study of 686 cases. J Am Acad Dermatol 29: 176-180 Kiec-Swierczynska M (1995) Occupational sensitivity to rubber. Contact

Dermatitis 32 : 171-172 Von Hintzenstern J, Heese A, Koch HU, Peters KP, Hornstein OP (1991) Frequency, spectrum and occupational relevance of type IV allergies to rubber chemicals. Contact Dermatitis 24:244-252

Diphenylguanidine is a rubber sensitizer that can induce immediate-type reactions and delayed-type contact allergy. It was formerly contained in "carba mix." Occupational exposure concerns finished rubber items and the rubber manufacturing industry. The most frequent occupational categories are metal industry, home-makers, health services and laboratories, and the building industry.

Suggested Reading

Bruze M, Kestrup L (1994) Occupational allergic contact dermatitis from diphenylguanidine in a gas mask. Contact Dermatitis 31 : 125-126 Conde-Salazar L, Del-Rio E, Guimaraens D, Gonzalez Domingo A (1993) Type IV allergy to rubber additives: a 10-year study of 686 cases. J Am Acad Dermatol 29: 176-180 Kiec-Swierczynska M (1995) Occupational sensitivity to rubber. Contact

Dermatitis 32 : 171-172 Mancuso G, Reggiani M, Berdondini RM (1996) Occupational dermatitis in shoemakers. Contact Dermatitis 34:17-22 Von Hintzenstern J, Heese A, Koch HU, Peters KP, Hornstein OP (1991) Frequency, spectrum and occupational relevance of type IV allergies to rubber chemicals. Contact Dermatitis 24:244-252

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