Glyceryl Trinitrate Glycerol Trinitrate

CAS Registry Number [55-63-0] O O"

Nitroglycerin is an explosive agent contained in dynamite, and an antianginal and vasodilator treatment available in systemic and topical forms. It is a well known irritant agent in dynamite manufacture. It can also cause allergic reactions in employees of explosives manufacturers, and in the pharmaceutical industry. Transdermal systems are the main source of iatrogenic sensitization. Nitroglycerin can cross-react with isosorbide dinitrate.

Suggested Reading

Aquilina S, Felice H, Boffa MJ (2002) Allergic reactions to glyceryl trini-trate and isosorbide dinitrate demonstrating cross-sensitivity. Clin Exp Dermatol 27:700-702 Kanerva L, Laine R, Jolanki R, Tarvainen K, Estlander T, Helander I (1991) Occupational allergic contact dermatitis caused by nitroglycerin. Contact Dermatitis 24:356-362 Machet L, Martin L, Toledano C, Jan V, Lorette G,Vaillant L (1999) Allergic contact dermatitis from nitroglycerin contained in 2 transdermal systems. Dermatology 198: 106-107

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