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240. Isoeugenol

Isoeugenol

CAS Registry Number [97-54-1] c/s-isoeugenol

CAS Registry Number [5912-86-7]

frans-Isoeugenol

CAS Registry Number [5932-68-3]

C/s- Isoeugenol

C/s- Isoeugenol

Trans- Isoeugenol

Isoeugenol is a mixture of two cis and trans isomers. It occurs in ylang-ylang and other essential oils. It is a common allergen of perfumes and cosmetics such as deodorants, and is contained in fragrance mix. Its presence in cosmetics is indicated in the INGREDIENTS series. Substitution by esters such as isoeugenyl acetate (not indicated on the package) does not always resolve the allergenic problem, because of the in vivo hydrolysis of the substitute into isoeugenol.

Suggested Reading

Rastogi SC, Johansen JD, Frosch P, Menne T, Bruze M, Lepoittevin JP, Dreier B, Andersen KE, White IR (1998) Deodorants on the European market: quantitative chemical analysis of 21 fragrances. Contact Dermatitis 38 : 29-35 Tanaka S, Royds C, Buckley D, Basketter DA, Goossens A, Bruze M, Svedman C, Menne T, Johansen JD, White IR, McFadden JP (2004) Contact allergy to isoeugenol and its derivatives: problems with allergen substitution. Contact Dermatitis 51: 288-291

241. Alpha-Isomethylionone

3-Buten-2-one, 3-Methyl-4-(2,6,6-Trimethyl-2-Cyclohexen-1-yl), 3-Methyl-4-(2,6,6-Trimethyl-2-Cyclohexen-1-yl)3-Buten-2-one, Cetone Alpha

CAS Registry Number [127-51-5]

As a fragrance allergen, a-isomethylionone has to be mentioned by name in cosmetics within the EU.

Suggested Reading

Frosch PJ (1998) Are major components of fragrances a problem? In: Frosch PJ, Johansen JD, White IR (eds) Fragrances. Beneficial and adverse effects. Springer, Berlin Heidelberg New York, pp 92-99

242. Isophorone Diamine

1-Amino-3-Aminomethyl-3,3,5-Trimethylcyclohexane, 3-Aminomethyl-3,5,5-Trimethylcyclohexylamine

CAS Registry Number [2855-13-2]

Isophorone diamine is widely used in urethane and epoxy coatings for light-stable, weather-resistant properties. It is used in water proofing and paving concreting, and in the manufacture of diisocyanates and polyamides as an epoxy resin hardener. It is a strong sensitizer and can cause airborne contact dermatitis.

Suggested Reading

Guerra L, Vincenzi, Bardazzi F, Tosti A (1992) Contact sensitization to isophoronediamine. Contact Dermatitis 27:52-53 Kelterer D, Bauer A, Elsner P (2000) Spill-induced sensitization to isophorone diamine. Contact Dermatitis 43: 110 Lodi A, Mancini LL, Pozzi M, Chiarelli G, Crosti C (1993) Occupational airborne allergic contact dermatitis in parquet layers. Contact Dermatitis 29:281-282

243. Isopropyl Myristate

Tetradecanoic Acid 1-Methyl Ethyl Ester CAS Registry Number [110-27-0]

Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sensitizer and a mild irritant.

Suggested Reading

Uter W, Schnuch A, Geier J, Lessmann H (2004) Isopropyl myristate recommended for aimed rather than routine patch testing. Contact Dermatitis 50: 242-244

244. N-Isopropyl-N-Phenyl-4-Phenylenediamine

IPPD, N-Isopropyl-N'-Phenyl-p-Phenylenediamine, N-(1-Methylethyl)-N'-Phenyl-1,4-Benzenediamine

CAS Registry Number [101-72-4]

This rubber chemical is used as an antioxidant and anti-ozonant.

The main occupational sources are tires.

Suggested Reading

Condé-Salazar L, Del-Rio E, Guimaraens D, Gonzalez Domingo A (1993) Type IV allergy to rubber additives: a 10-year study of 686 cases. J Am Acad Dermatol 29: 176-180

Hervé-Bazin B, Gradiski D, Duprat P,Marignac B, Foussereau J, Cavelier C, Bieber P (1977) Occupational eczema from W-isopropyl-W'-phenyl-paraphenylenediamine (IPPD) and W-dimethyl-1,3 butyl-W '-phenyl-paraphenylenediamine (DMPPD) in tyres. Contact Dermatitis 3: 1-15

Von Hintzenstern J, Heese A, Koch HU, Peters KP, Hornstein OP (1991) Frequency, spectrum and occupational relevance of type IV allergies to rubber chemicals. Contact Dermatitis 24: 244-252

245. Ketoprofen

CAS Registry Number [22071-15-4]

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Allergic To Everything

Allergic To Everything

The human body And Todays chemical infested world. Here is a news flash You are not allergic to pollen, pet dander, or whatever it is that makes your body revolt Rather, your body just can not handle that one thing, what ever it is, anymore, due to the massive barrage of toxic chemicals you and everyone else are ingesting every single day.

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